Claus Hellerbrand Selected Research

xanthohumol

1/2021	Xanthohumol, a Prenylated Chalcone Derived from Hops, Inhibits Growth and Metastasis of Melanoma Cells.
1/2019	Therapeutic Application of Micellar Solubilized Xanthohumol in a Western-Type Diet-Induced Mouse Model of Obesity, Diabetes and Non-Alcoholic Fatty Liver Disease.
1/2018	An iso-α-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice.
1/2015	The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.
2/2013	Xanthohumol suppresses inflammatory response to warm ischemia-reperfusion induced liver injury.
1/2012	Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.
7/2010	Xanthohumol feeding does not impair organ function and homoeostasis in mice.
7/2010	Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis.
2/2010	Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells.

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Claus Hellerbrand Research Topics

Disease

53	Fibrosis (Cirrhosis) 10/2022 - 04/2003
44	Neoplasms (Cancer) 11/2021 - 05/2005
38	Hepatocellular Carcinoma (Hepatoma) 03/2021 - 05/2005
30	Inflammation (Inflammations) 01/2020 - 04/2003
27	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 12/2004
23	Liver Diseases (Liver Disease) 10/2022 - 01/2004
16	Melanoma (Melanoma, Malignant) 01/2021 - 04/2003
15	Non-alcoholic Fatty Liver Disease 01/2019 - 01/2010
15	Fatty Liver 01/2018 - 09/2006
12	Neoplasm Metastasis (Metastasis) 11/2021 - 02/2009
10	Hypoxia (Hypoxemia) 04/2018 - 07/2008
10	Chronic Hepatitis C 08/2011 - 04/2003
9	Infections 10/2018 - 04/2003
8	Body Weight (Weight, Body) 01/2018 - 01/2009
8	Alcoholic Fatty Liver 06/2015 - 01/2011
6	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019 - 01/2010
6	Hemochromatosis (Bronze Diabetes) 04/2008 - 07/2003
5	Liver Neoplasms (Liver Cancer) 11/2021 - 11/2012
5	Obesity 01/2019 - 01/2011
5	Carcinoma (Carcinomatosis) 09/2014 - 01/2005
5	Disease Progression 03/2013 - 08/2007
4	Necrosis 01/2018 - 10/2010
4	Hepatitis C 01/2012 - 04/2005
3	Alcoholic Liver Diseases (Alcoholic Liver Disease) 07/2019 - 04/2008
3	Insulin Resistance 12/2018 - 07/2011
3	Carcinogenesis 01/2018 - 05/2005
3	Colonic Neoplasms (Colon Cancer) 06/2015 - 06/2010
3	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 09/2011 - 04/2008
3	Virus Diseases (Viral Diseases) 04/2008 - 08/2005
2	Cholangiocarcinoma 01/2021 - 01/2009
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020 - 12/2017
2	Sclerosis 01/2019 - 01/2005
2	Squamous Cell Carcinoma of Head and Neck 01/2018 - 09/2014
2	Pancreatic Neoplasms (Pancreatic Cancer) 04/2017 - 11/2011

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 11/2021 - 04/2003
20	Messenger RNA (mRNA)IBA 01/2016 - 04/2003
12	LipidsIBA 10/2018 - 03/2010
11	ChemokinesIBA 02/2012 - 09/2003
9	xanthohumolIBA 01/2021 - 02/2010
9	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 04/2009
8	Transcription Factors (Transcription Factor)IBA 11/2019 - 10/2008
8	EnzymesIBA 03/2016 - 09/2003
8	AdiponectinIBA 01/2013 - 09/2006
7	CytokinesIBA 01/2018 - 04/2008
7	CollagenIBA 01/2017 - 11/2008
6	Protein Isoforms (Isoforms)IBA 01/2020 - 04/2009
6	Small Interfering RNA (siRNA)IBA 12/2018 - 12/2010
6	Cadherins (E-Cadherin)IBA 12/2017 - 01/2009
6	IronIBA 12/2015 - 07/2003
6	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA 04/2013 - 01/2005
6	Codon (Codons)IBA 04/2008 - 12/2003
5	Mechanistic Target of Rapamycin Complex 2IBA 11/2021 - 04/2017
5	LigandsIBA 01/2021 - 08/2007
5	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2012
5	Phosphotransferases (Kinase)IBA 01/2021 - 08/2011
5	Ethanol (Ethyl Alcohol)IBA 03/2019 - 04/2015
5	Sorafenib (BAY 43-9006)FDA Link 01/2019 - 08/2011
5	Methionine (L-Methionine)FDA Link 01/2016 - 05/2010
5	Biomarkers (Surrogate Marker)IBA 01/2012 - 08/2007
5	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 12/2011 - 09/2003
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2022 - 07/2008
4	Transaminases (Aminotransferases)IBA 01/2020 - 01/2011
4	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2020 - 04/2009
4	Sirolimus (Rapamycin)FDA Link 12/2018 - 02/2009
4	AcidsIBA 12/2018 - 04/2012
4	Ferritins (Ferritin)IBA 12/2015 - 06/2005
4	Pemetrexed (MTA)FDA Link 04/2013 - 05/2010
4	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2011 - 12/2007
4	Transforming Growth Factor beta1 (TGF beta 1)IBA 04/2008 - 12/2003
3	TOR Serine-Threonine KinasesIBA 11/2021 - 04/2017
3	Neuropeptide YIBA 01/2020 - 12/2008
3	EndotoxinsIBA 01/2020 - 12/2004
3	Cyclin D1IBA 01/2020 - 01/2009
3	Biological ProductsIBA 01/2019 - 08/2009
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 12/2011
3	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 12/2015 - 11/2011
3	ProteomeIBA 03/2013 - 01/2010
3	Transforming Growth Factor beta (TGF-beta)IBA 10/2011 - 12/2007
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2010 - 02/2009
3	NF-kappa B (NF-kB)IBA 06/2010 - 01/2007
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 10/2022 - 11/2011
2	Mechanistic Target of Rapamycin Complex 1IBA 11/2021 - 01/2021
2	Chalcone (Benzalacetophenone)IBA 01/2021 - 02/2010
2	LipopolysaccharidesIBA 01/2020 - 01/2012
2	Bile Acids and Salts (Bile Acids)IBA 01/2020 - 10/2010
2	TubulinIBA 11/2019 - 07/2008
2	regorafenibIBA 01/2019 - 01/2018
2	Conditioned Culture MediaIBA 12/2018 - 04/2017
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 12/2018 - 06/2014
2	RNA (Ribonucleic Acid)IBA 01/2018 - 01/2005
2	SolutionsIBA 01/2018 - 04/2015
2	maltodextrinIBA 01/2018 - 04/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2017 - 11/2011
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2016 - 09/2010
2	Choline (Choline Chloride)IBA 01/2016 - 02/2012
2	Lactic Acid (Lactate)FDA LinkGeneric 09/2014 - 02/2010

Therapy/Procedure

20	Therapeutics 11/2021 - 04/2007
6	Liver Transplantation 12/2015 - 04/2008
6	Ligation 08/2011 - 07/2004
2	Drug Therapy (Chemotherapy) 01/2018 - 02/2017